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A highly convergent and scalable second-generation synthesis of the fully functionalized HIJKLMN-ring segment of Caribbean ciguatoxin C-CTX-1, the primary toxin responsible for ciguatera fish poisoning in the Caribbean Sea and the Northeast Atlantic regions, has been accomplished. Key aspects of the synthetic approach include the efficient syntheses of the HI- and KLM-ring fragments on gram scales, a convergent fragment coupling toward the HIJKLM-ring skeleton based on the Suzuki–Miyaura coupling strategy, and optimized iron hydride-catalyzed hydrogen atom transfer-mediated olefin coupling conditions for constructing the N-ring. Source link

Even as volcanic smoke chokes the air around its pilot plant in Iceland, Carbon Recycling International is celebrating a win with the announcement of a third commercial-scale facility in China that will convert green hydrogen and captured carbon dioxide into methanol. CRI’s Iceland facility runs on CO2, water, and renewable electricity from the Svartsengi geothermal power station, which is about 40 km southwest of Reykjavik. CRI says the low-carbon energy source allows it to produce 4,000 metric tons (t) of methanol per year with a greenhouse gas footprint just 10–20% that of conventional methanol. The firm had to evacuate in…

Ever wondered if you could build a robot controlled by chemical reactions? [Marb] explores this wild concept in his video, merging chemistry and robotics in a way that feels straight out of sci-fi. From glowing luminol reactions to creating artificial logic gates, [Marb]—a self-proclaimed tinkerer—takes us step-by-step through crafting the building blocks for what might be the simplest form of a chemical brain. In this video, the possibilities of an artificial chemical brain take centre stage. It starts with chemical reactions, including a fascinating luminol-based clock reaction that acts as a timer. Then, a bionic robot hand makes its debut,…

An in-depth report conducted by the New York Times follows how the Sinaloa Cartel is recruiting young college students studying chemistry to make Fentanyl. The Times report included interviews with seven fentanyl cooks, three chemistry students, two high-ranking operatives and a high-level recruiter. All of them work for the Sinaloa Cartel, which the U.S. government says is largely responsible for the fentanyl pouring over the southern border. The cartels “know we are now focused on the illicit trafficking of these precursor chemicals around the world,” said Todd Robinson, the State Department’s assistant secretary of the Bureau of International Narcotics and…

Atomically precise copper nanoclusters (NCs) attract research interest due to their intense photoluminescence, which enables their applications in photonics, optoelectronics, and sensing. Exploring these properties requires carefully designed clusters with atomic precision and a detailed understanding of their atom-specific luminescence properties. Here, we report two copper NCs, [Cu4(MNA)2(DPPE)2] and [Cu6(MNA-H)6], shortly Cu4 and Cu6, protected by 2-mercaptonicotinic acid (MNA-H2) and 1,2-bis(diphenylphosphino)ethane (DPPE), showing “turn-off” mechanoresponsive luminescence. Single-crystal X-ray diffraction reveals that in the Cu4 cluster, two Cu2 units are appended with two thiols, forming a flattened boat-shaped Cu4S2 kernel, while in the Cu6 cluster, two Cu3 units form an adamantane-like…

Credit: Pixabay/CC0 Public Domain UCLA chemists have found a big problem with a fundamental rule of organic chemistry that has been around for 100 years—it’s just not true. And they say, It’s time to rewrite the textbooks. Organic molecules, those made primarily of carbon, are characterized by having specific shapes and arrangements of atoms. Molecules known as olefins have double bonds, or alkenes, between two carbon atoms. The atoms, and those attached to them, ordinarily lie in the same 3D plane. Molecules that deviate from this geometry are uncommon. The rule in question, known as Bredt’s rule in textbooks, was…

The Boston-based computational chemistry start-up Rowan Scientific has secured $2.1 million in preseed funding from investors including Pillar VC and AI Grant. The firm was formed last year by siblings Corin and Ari Wagen and their friend Eli Mann. The new venture aims to compete with well-established players in the space, notably Schrödinger. Both firms deploy physics-based computational services that help chemists understand interactions between compounds and protein drug targets. But Corin Wagen, the new firm’s CEO, says Rowan’s tools are built using machine learning (ML) in addition to physics-based methods, enabling users to get the best of both worlds.…

Resonance structures of metal cation–phosphonoenolate. Credit: The Journal of Organic Chemistry (2024). DOI: 10.1021/acs.joc.4c01140 The Wadsworth–Emmons (HWE) reaction is a fundamental reaction in organic chemistry, widely used to create conjugated carbonyl compounds. Conjugated carbonyl compounds are used in many industries for synthesizing perfumes, plastics, and pharmaceuticals and are also involved in biological processes. Consequently, methods for improving HWE reactions are an active area of research. One potential application of HWE reactions is to develop (E)-isomers of conjugated carbonyl compounds that are useful for synthesizing chemicals called hynapene analogs with promising anti-cancer properties. Unfortunately, traditional HWE reaction methods are sometimes inconsistent…

GREAT chemistry helped skilled students win a science award. A talented duo from Coleg Cambria – which has sites in Northop, Llysfasi, Deeside and Wrexham – were part of the Yale Sixth winning team taking part in the Royal Society of Chemistry Young Analyst Competition. Year 12 learners Grace Shore and Megan Roberts completed a series of tasks and challenges to emerge victorious amongst their college cohort. They were joined by 10 other students from Yale Sixth in the North West regional heat of the competition. Nora Richardson, a Chemistry lecturer and Curriculum Lead at Yale Sixth, was “very proud”…

The coexistence and coupling of photoluminescence and ferroelasticity in a single matter are vitally important for developing multifunctional materials and devices. However, the effective construction of ferroelastics with efficient photoluminescence, especially in the ultraviolet range, is a great challenge. In this work, a salt cocrystal, (DPA)(DPAH)PF6 (DPA = diphenylamine, DPAH = diphenylamine cation), with ultraviolet emission and ferroelasticity was reported by introducing the anion group PF6– in the parent DPA crystal. Besides, the thermally triggered order–disorder transition of PF6– groups leads to a ferroelastic phase transition at ∼340 K with the Aizu notation of 2/mF1̅. In addition, (DPA)(DPAH)PF6 displays a…